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Cognitive therapy and antidepressant medication have comparable effects. This graph shows the response of outpatients who had moderate-to-severe depression to cognitive therapy (CT), antidepressant medication (ADM) or placebo. Patients who were assigned to ADM or to CT showed a significantly higher response rate after 8 weeks of treatment than those who were assigned to placebo. After 16 weeks of treatment the response rates of ADM and CT were almost identical.
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a | During acute depression, amygdala activity is increased (red) and prefrontal activity is decreased (blue) relative to activity in these regions in healthy individuals. b | Cognitive therapy (CT) effectively exercises the prefrontal cortex (PFC), yielding increased inhibitory function of this region. c | Antidepressant medication (ADM) targets amygdala function more directly, decreasing its activity. d | After ADM or CT, amygdala function is decreased and prefrontal function is increased. The double-headed arrow between the amygdala and the PFC represents the bidirectional homeostatic influences that are believed to operate in healthy individuals.






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